If I include the word 'significant' in a coursework question will it be enough to ensure the question is appropriate?

By itself, it will not ensure the question is appropriate. Although it is a good idea to reference significance directly in the question, the question must require learners to assess significance, rather than simply describe it. Coursework questions that begin 'Assess the significance of... ', or 'How significant was...?' are better than a question that begins 'What was the significance of...?'

The question must not turn into a causation question such as 'Was the Depression the most significant reason why Hitler was able to come to power?' This question tests the ability of learners to explain the relative importance of different reasons why Hitler came to power, rather than the significance of the Depression - which was significant in different ways.

The Coursework Handbook explains this in more detail. All teachers should read the handbook carefully before starting on coursework.